Topic 6 : LivAdip - Liver and Adipose Tissue Physiomics in Metabolic Diseases

Joel Haas, PhD, HDR

Research director Inserm, Team Leader

ORCID : 0000-0002-0028-5988

I am a full-time INSERM research director with extensive experience studying glucose and lipid metabolism in the context of cardiometabolic disease. Prior to my PhD, I worked as a research associate at the Joslin Diabetes Center at Harvard Medical School studying the contribution of defective hepatic insulin signaling to complications of type-2 diabetes. I then obtained a PhD in biochemistry and molecular biology at the University of California-San Francisco, studying the physiological roles of triglyceride synthesizing enzymes (DGAT1 and DGAT2). In 2013, I joined the INSERM laboratory UMR1011 in Lille, (Nuclear Receptors, Metabolic and Cardiovascular Diseases) for a post-doctoral fellowship and in 2019 I was obtained a full-time tenured researcher position in the same department. I currently co-lead a team entitled “LivAdip: Liver and Adipose Tissue Physiomics in Metabolic Disease” with Dr. Delphine Eberlé. I have obtained numerous prestigious awards including the EMBO Long Term Fellowship, French ANR Young Researcher Grant, and an ERC Starting grant. My main research project focuses on how metabolic factors impact the function of the innate immune system in pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD).

Delphine Eberlé, PhD, HDR

Professor, Lille University, Team leader

ORCID : 0000-0003-2211-6146

I am professor of Physiology at Lille University. I am particularly interested in exploring the role of adipose tissue plasticity in the context of obesity and its associated complications MASLD (Metabolic dysfunction-associated steatotic liver disease). Passionate about human nutrition, I began my scientific journey at the École Nationale Supérieure d'Agronomie in Rennes, earning an engineering degree in Agronomy with a focus on Biochemistry and Genetics. I obtained my PhD in Paris studying the genetics of obesity, with a focus on the lipogenic transcription factor SREBP-1. I then completed postdoctoral trainings at the Joslin Diabetes Center in Boston and at the University of California-San Francisco (USA), where I focused on mechanisms of inflammation development and resolution in obesity and atherosclerosis. In 2013, I joined the Biology Department at the Faculty of Science and Technology at Lille University as an Associate Professor, and led studies on the developmental programming of adipose tissue and obesity, particularly how early postnatal nutrition influence long-term metabolic health via epigenetic mechanisms. In 2020, I joined the UMR1011 research unit and the European Genomic Institute for Diabetes (EGID), to continue my research on adipose tissue function in metabolic diseases. I currently co-direct the thematic group LivAdiP, focusing on liver-adipose tissue crosstalk in obesity and MASLD combining multidisciplinary approaches from omics to physiology. Since 2024, I have served as Vice President of AFERO, the French Association for Studies and Research on Obesity.

Lucas BUTTIN,

Engineer, INSERM

Lucas.buttin[chez]inserm[point].fr

ORCID : 0009-0006-1442-3778

After completing a Bachelor’s degree in Cellular Biology and Physiology, followed by a Master’s degree in Biology and Health « Precision Health »  at the University of Lille, I joined the U1011 research unit as a research engineer within Bart Staels’ team. Under the supervision of Pr. Delphine Eberlé, I am currently investigating the role of the nuclear receptor RORα in adipocyte plasticity during non-shivering thermogenesis. This work aims to better characterize the molecular mechanisms underlying adaptive thermogenesis and metabolic regulation.

Arthur GRENON

Engineer, Lille University

arthur.grenon[chez]univ-lille[point].fr

ORCID : 0009-0009-3717-1341

Project manager (APTEEUS) during 2 years: Development of in vitro phenotypical tests for high-throughput screening of repurposable molecules

Study engineer (UMR1011): Involved in scRNAseq project (EvoLiLiD), sc/snRNAseq libraries preparation and scRNAseq analysis

Anne-Sophie JENEQUIN

Engineer in mass spectrometry, INSERM

ORCID : 0009-0003-6205-0409

Anne-Sophie obtained a Master's degree in Biotechnology in 2020, and began her career as a Research Engineer in analytical chemistry, specializing in HPLC-MS/MS, at the Institut Charles Viollette in Villeneuve d’Ascq, FR. Her primary mission was to identify molecules with antibacterial properties, aiming to propose new classes of drugs capable of combating bacteria resistant to existing treatments. Subsequently, she worked in the private sector as a Laboratory Technician specializing in metabolomic studies at Aliri, where she utilized her chromatography skills for high-precision analyses and collaborated with various companies. Finally, she joined the LivAdip team in the department UMR1011as a Research Engineer in analytical chemistry, specializing in HPLC-MS/MS analyses. Her role involves developing an MS platform to conduct metabolomic analyses in close collaboration with research groups