SaKnow-How of the Unit
Our laboratory has technical expertise at the cutting edge of research in various fields:
- Biochemistry :
- Measurement of circulating biochemical parameters (glucose, insulin, transaminases, free fatty acids, etc.)
- Measurement of lipid and lipoprotein concentrations
- Determination of lipid distribution profiles
- Determination of bile acid profiles (21 species) in biological media (plasma, feces, bile)
Analyses in humans and pre-clinical models
- Histology :
- Ultra-microtomy
- Immunohistochemistry
- Microscopy
- Laser microdissection station
- Immunophenotyping :
- Flow cytometry
- Cell Biology :
- Cell lines
Human and murine liver cells, murine preadipocyte cells, murine fibroblasts, human leukocyte cells, murine beta-pancreatic cells, human kidney cells, murine enteroendocrine cells
- Primary crops
Human and murine hepatocytes, monocytes and macrophages,
Human and murine intestinal organoids
- Molecular Biology :
- Microarray
- Proteomics
- Real-time PCR
- In Vivo :
- Animal imaging (small animal CT/MRI)
- Bone marrow transplantation
- Measurement of metabolic parameters in animals
- Pythysmographic measurements (lung function)
- Measures of cardiovascular function
- Genetically modified animal models
- Animal models for the study of allergy
- Collaboration with clinical research