Presentation of UMR1011
The laboratory is a Mixed Research Unit (MRU) funded by INSERM, Lille University, Hospital Center of Lille and Lille Pasteur Institute.
The unit studies the biological mechanisms regulating the development and the progression of Type 2 Diabetes (T2D), Metabolic dysfunction Associated to Steatotic Liver Diseases (MASLD) and their cardiovascular complications, to develop preventive and therapeutic strategies.
To achieve this goal, the lab studies gene regulation involved in these diseases, with a focus on nuclear receptors (NRs), which are potentials therapeutics targets. Recently, the unit contributed to:
- Demonstrated the role of NRs in the perturbations of the metabolism during T2D, MASLD and their complications
- Characterized the effects of NRs in inflammatory processes in adipose tissue and vessel wall
However, all the roles of NRs in the development of T2D, MASLD and their complications are still not elucidated. To achieve these goals, UMR1011 is divided into 8 research topics:
Topic 1 (Inter-organ cross talk in cardiometabolic diseases) studies the metabolic functions of NRs (FXR, Rev-erbα, RORα) and their implication as potential therapeutic targets in pathologies associated with metabolic syndrome.
Topic 2 (Cardiac disorders, blood flow abnormalities and haemostasis) explores the molecular signatures of bleeding disorders (von Willebrand disease, haemophilia), as well as the impact of these conditions on vascular integrity, the occurrence of, and management of, cerebral haemorrhages. Finally, our team is investigating the consequences, causes and treatment of flow abnormalities on the vascular endothelium and the degeneration of valvular bioprostheses.
Topic 3 (Immuno-metabolic dialogue in obesity and its comorbidities) studies the role of RNs in immune system cells such as mast cells and B lymphocytes in the pathophysiology of metabolic diseases, with a particular focus PPARγ.
Topic 4 (Integrated transcriptional analysis of liver diseases) identifies the molecular mechanisms of gene regulation orchestrated by NRs, in order to discover new regulatory pathways and better define molecules for therapeutics strategies.
Topic 5 (Nuclear receptors in circadian biology) has developed a new research topic devoted to circadian regulation of metabolism and inflammation, focusing on the components of the circadian clock and associated nuclear receptors, such as Rev-erbs and RORs.
Topic 6 (LivAdip - Physiomics of the liver and adipose tissue in metabolic diseases) studies the role of the liver and adipose tissue in the pathogenesis of obesity and MASLD, as well as the mechanisms of regression or persistence of the disease following weight loss.
Topic 7 (ENDO-PLAST - Roles of plasticity in endothelial cells and metabolic reprogramming in diseases, Atip-Avenir team) seeks to characterize the role of endothelial cell dysfunction in the development of cardiovascular disease and cancer.
Topic 8 (Sinusoidal and ECM remodelling in liver diseases, ATIP Avenir Team) focuses on the mechanisms that control the progression of liver diseases and liver regeneration, with the aim of identifying new therapeutic strategies to restore normal liver function