Post-Doctoral position immunometabolism : dendritics cells and psoriasis

Offer description

We are looking for a highly motivated post-doctoral fellow interested in immunometabolism and metabolic control of inflammatory diseases in particular psoriasis and colitis. This project aims to decipher the molecular links between dendritic cell migration, intracellular metabolism and the development of psoriasis and colitis using in vitro cellular models,  preclinical mouse models and human cohorts, combined with interdisciplinary state-of-the art approaches (high dimensional flow and mass cytometry, Single cell-RNA-seq, Metabolomics and bioinformatic analysis).

The candidate will join our team within the research laboratory INSERM UMR1011 located in Lille (France) and directed by Pr. Bart Staels. Our research unit is part of the “Laboratory of Excellence” European Genomic Institute of Diabetes (EGID, http://www.egid.fr), INSERM, Institut Pasteur de Lille, CHU de Lille and Lille University, and attracts students from around the world by offering high-level training in biomedical sciences. The unit develops multidisciplinary research at the interface of physiology, cell biology, biochemistry and medicine using cutting-edge, innovative technologies.

The successful post-doctoral fellow will work directly with Dr. David Dombrowicz, and interact with other scientists, national and international collaborators, post-doctoral fellows, bioinformaticians, PhD students and technicians. We offer a 1-year contract (renewable for at least 1 additional year) starting October 2022 or later upon agreement. We also encourage and would support candidates’ applications for supplementary funding (Marie Curie, EMBO, FRM….). Remuneration and benefits will be based on the salary scale for public-sector employees considering previous experience.

- Required: PhD with a strong background in immunology, inflammation, metabolism and/or skin biology.

  Background in bioinformatic analysis would be a strong additional asset

- Good experience with animal experimentation

  Authorization for animal experimentation FELASA at least B level, preferably C level would be highly appreciated.

- Mastery of basic techniques in cell and molecular biology.

- Fluent in English with good written and oral communication skills

- Autonomous, yet able to efficiently work within a team

- Performing experiments on preclinical mouse models

- Immunological and molecular analyses of human and mouse samples.

- Bioinformatic/statistical analyses of -omics data

- Preparation of scientific articles and presentation at local and international meetings

Your application:

Candidates should send a CV with a publication list, a short summary of research achievements and mastered techniques, and contact information of at least three references to: David Dombrowicz (david.dombrowicz[chez]pasteur-lille[point].fr)

Benefits

Salary will be commensurate with experience depending on the INSERM salary scale for postdoctoral fellows (<2 years experience: ~2600€/month before taxes. 2-4 years experience: ~3000€/month before taxes).

Selection process

First screening will be based on CV, experience and written references. Selected candidates will be invited to give a seminar based on their past research experience. Every effort will be made for serious candidatures to visit the lab in person and discuss with potential future colleagues.

Required Research Experiences

• RESEARCH FIELD

Biological sciences › Biology

• YEARS OF RESEARCH EXPERIENCE

1 - 4

Offer Requirements

• REQUIRED LANGUAGES

ENGLISH: Good

Skills/Qualifications

Candidate profile:

- Required: PhD with a strong background in immunology, inflammation, metabolism and/or skin biology.

- Good experience with animal experimentation

- Mastery of basic techniques in cell and molecular biology.

- Fluent in English with good written and oral communication skills

- Autonomous, yet able to efficiently work within a team

Workplace location

Inserm U1011.

Institut Pasteur de Lille

1, r. Prof. Calmette BP245

59019 Lille France