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Nuclear Receptors and Cardiac Function - Prof. David Montaigne

David Montaigne, MD, PhD
Contact info:
INSERM U1011 -Institut Pasteur de Lille-Université Lille Nord de France - EGID
1 rue Calmette, BP245, 59019 Lille
Research Laboratory J & K, Faculty of Medicine - Research Center
Boulevard du Professeur J. Leclercq, 59045 Lille Cedex - France
Tel. +33 (0)3.2097.4216
Email : davidmontaigne@hotmail.com

 

Short biography:

David Montaigne, is a 37-year-old academic cardiologist (MD) on a position of Professor in cardiac physiology at the School of Medicine of Lille (Université Lille, France). He obtained his Doctoral Thesis of Biological Sciences (PhD) in 2010 (Université Lille) and is accredited to supervise research (HDR). He has joined the INSERM unit UMR1011 (Lille), headed by Prof. Bart Staels since 2013. In this team, David Montaigne leads “cardiovascular translational research” projects. David Montaigne is also in charge of the cardiovascular exploration department at the University Hospital CHU Lille since his return from a post-doctoral fellowship in London in 2014 (Prof A Tinker,QMUL and Prof D Hausenloy,UCL). He has published 50 papers in the field of translational research regarding cardiac disease pathophysiology (h factor 15) with recent first-author publications in J Am Coll Cardiol and Circulation journals.

David Montaigne and his collaborators have significant experience in translational research exploring cardiovascular disease pathophysiology illustrated by several first-line academic publications in cardio-vascular journals.

 

Key words:

Cardiac function & energetic metabolism, mitochondrial function, ischemia-reperfusion, type 2 diabetes.

 

  • Research interest:

Mitochondria, cardiac function and cardioprotection.

Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide. Patients suffering from CHD face myocardial ischemia-reperfusion injury, not only when they experience an acute myocardial infarction, but also during the cardiopulmonary bypass required for coronary artery by-pass graft surgery (CABG), a major intervention for coronary revascularization. During cardiac surgery, i.e. coronary artery bypass graft and/or valve replacement, the heart is excluded from the systemic circulation by aorta cross clamping allowing the surgeon to work in a blood-free operative field but imposing ischemia-reperfusion damage to the myocardium. Preventing cardiomyocyte death after ischemia-reperfusion is still a first-line unmet clinical need, since most recent cardioprotective approaches failed in the clinic.

We hypothesize that poor cardiac mitochondrial function, as encountered in diabetic and old patients, is responsible for poor myocardial function and IR tolerance. We thus anticipate that boosting cardiac mitochondrial function by interfering with nuclear receptor signaling is a relevant pharmacological target in these patients.

Our translational research project ranges from clinical trial to human myocardial sample exploration and molecular biology and is designed to bring evidence and relevant approaches to improve patient care.

This project will benefit of the quite unique opportunity of a cooperative effort of university hospital clinicians with basic science researchers with international established expertise in the field of nuclear receptor, pharmacology and exploration of both rodent and human myocardium. The project is supported by granted access to state-of-the-art technological platforms and daily access to human myocardial samples. The group belongs to the European Genomic Institute for Diabetes and as such has access to the most recent technologies in animal facilities, genome-wide transcriptomics, cellular and molecular biology.

 

  • Our Competences
  • Mouse isolated perfused heart,
  • Echocardiography,
  • Cardiac MRI,
  • Human myocardial tissue collection,
  • Clinical trial.

Montaigne D, Coisne A, Marechal X, Staels B. Comment on Patel et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes 2016;65:85-95.

Diabetes. 2016 Feb;65(2):e1-2.

 

Montaigne D, Coisne A, Sosner P, Lacroix D, Hadjadj S. SURDIAGENE Study Group. Electrical atrial vulnerability and renal complications in type 2 diabetes.

Diabetologia. 2015 Dec 24.

 

Ringle A, Richardson M, Juthier F, Rousse N, Polge AS, Coisne A, Duva-Pentiah A, Abda AB, Banfi C, Montaigne D, Vincentelli A, Prat A. Ross procedure is a safe treatment option for aortic valve endocarditis: Long-term follow-up of 42 patients.

Int J Cardiol. 2016 Jan 15;203:62-8.

 

Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R, Tinker A. Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling.

J Biol Chem. 2015;290(31):19233-44.

 

Coisne A, Modine T, Fayad G, Mouton S, Binda C, Richardson M, Koussa M, Montaigne D. The slope of the stretch-strain relationship as a non-invasive contractility index: Insights from mitral regurgitation surgery.

Int J Cardiol. 2015;194:75-7.

 

Montaigne D, Maréchal X, Lacroix D, Staels B. From cardiac mitochondrial dysfunction to clinical arrhythmias.

Int J Cardiol. 2015;184:597-9.

 

Grossin N, Auger F, Niquet-Leridon C, Durieux N, Montaigne D, Schmidt AM, Susen S, Jacolot P, Beuscart JB, Tessier FJ, Boulanger E. Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice.

Mol Nutr Food Res. 2015;59(5):927-38.

 

Sosner P, Hulin-Delmotte C, Saulnier PJ, et al.; SURDIAGENE Study Group. Cardiovascular prognosis in patients with type 2 diabetes: contribution of heart and kidney subclinical damage.

Am Heart J. 2015;169(1):108-14.

 

Souissi Z, Guédon-Moreau L, Boulé S, Kouakam C, Finat L, Marquié C, Brigadeau F, Wissocque L, Mouton S, Montaigne D, Klug D, Kacet S, Lacroix D. Impact of remote monitoring on reducing the burden of inappropriate shocks related to implantable cardioverter-defibrillator lead fractures: insights from a French single-centre registry.

Europace. 2015 Oct 25

 

Debry N, Sudre A, Amr G, Delhaye C, Schurtz G, Montaigne D, Koussa M, Modine T. Transcatheter aortic valve implantation for paradoxical low-flow low-gradient aortic stenosis patients.

Catheter Cardiovasc Interv. 2015 Oct 1.

 

Montaigne D, Pentiah AD. Mitochondrial cardiomyopathy and related arrhythmias.

Card Electrophysiol Clin. 2015;7(2):293-301.

 

Marciniak C, Marechal X, Montaigne D, Neviere R, Lancel S. Cardiac contractile function and mitochondrial respiration in diabetes-related mouse models.

Cardiovasc Diabetol. 2014, 13, 118

 

Coisne A, Levy F, Malaquin D, Richardson M, Quéré JP, Montaigne D, Tribouilloy C. Feasibility of Doppler hemodynamic evaluation of primary and secondary mitral regurgitation during exercise echocardiography.

Int J Cardiovasc Imaging. 2014 Oct 18

 

Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, Richard V, Neviere R, Edme JL, Lefebvre P, Staels B. Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.

Circulation. 2014;130(7):554-64.

 

Escande W, Duva Pentiah A, Coisne A, Mouton S, Richardson M, Polge AS, Ennezat PV, Tillie-Leblond I, Montaigne D. Left ventricular myocardial performance index predicts poor outcome during COPD exacerbation.

Int J Cardiol., In Press, Available online 22 March 2014.

 

Coquerel D, Neviere R, Delile E, Mulder P, Marechal X, Montaigne D, Renet S, Remy-Jouet I, Gomez E, Henry JP, do Rego JC, Richard V, Tamion F. Gene Deletion of Protein Tyrosine Phosphatase 1B Protects Against Sepsis-Induced Cardiovascular Dysfunction and Mortality.

Arterioscler Thromb Vasc Biol. 2014 Feb 27.

 

Saulnier PJ, Gand E, Ragot S, Ducrocq G, Halimi JM, Hulin-Delmotte C, Llaty P, Montaigne D, Rigalleau V, Roussel R, Velho G, Sosner P, Zaoui P, Hadjadj S; for the SURDIAGENE Study Group. Association of Serum Concentration of TNFR1 With All-Cause Mortality in Patients With Type 2 Diabetes and Chronic Kidney Disease: Follow-up of the SURDIAGENE Cohort.

Diabetes Care. 2014 Mar 12.

 

Ouk T, Gautier S, Pétrault M, Montaigne D, Maréchal X, Masse I, Devedjian JC, Deplanque D, Bastide M, Nevière R, Duriez P, Staels B, Pasquier F, Leys D, Bordet R. Effects of the PPAR-α agonist fenofibrate on acute and short-term consequences of brain ischemia.

J Cereb Blood Flow Metab. 2014 Jan 8.

 

Neviere R, Edme JL, Montaigne D, Boleslawski E, Pruvot FR, Dharancy S. Prognostic implications of preoperative aerobic capacity and exercise oscillatory ventilation after liver transplantation.

Am J Transplant. 2014;14(1):88-95.

 

Mouton S, Duva Pentiah A, Domanski O, Coisne A, Richardson M, Neicu DV, Ben Abda A, Polge AS, Montaigne D. Aortic valve stenosis: survey on practice in the north of France.

Int J Cardiol. 2013;168(5):5031-2.

 

Montaigne D, Marechal X, Lefebvre P, Modine T, Fayad G, Zerimech F, Boulanger E, Lacroix D, Staels B, Neviere R. Mitochondrial dysfunction as an arrhythmogenic substrate : a translational proof-of-concept study in patients with metabolic syndrome developing post-operative atrial fibrillation.

J Am Coll Cardiol. 2013;62(16):1466-73.

 

Palud A, Marciniak C, Montaigne D, Marechal X, Ballot C, Hassoun SM, Decoster B, Neviere R, Lancel S. Macrophage migration inhibitory factor inhibition is deleterious for high-fat diet-induced cardiac dysfunction.

PLoS One. 2013;8(3):e58718.

 

Preau S, Montaigne D, Modine T, Fayad G, Koussa M, Tardivel M, Durocher A, Saulnier F, Marechal X, Neviere R. Macrophage Migration Inhibitory Factor Induces Contractile and Mitochondria Dysfunction by Altering Cytoskeleton Network in the Human Heart.

Crit Care Med. 2013;41(7):e125-33.

 

Neviere R, Pentiah AD, Montaigne D, Wurtz A. Pectus excavatum repair improves cardiovascular function at maximal exercise by facilitating heart filling.

Eur J Cardiothorac Surg. 2013 Mar;43(3):661.

 

Montaigne D, Hurt C, Neviere R. Mitochondria death/survival signaling pathways in cardiotoxicity induced by anthracyclines and anticancer-targeted therapies.

Biochem Res Int. 2012;2012:951539.

 

Hurt C, Coisne A, Modine T, Edme JL, Marechal X, Fayad G, Koussa M, Duva Pentiah A, Neviere R, Montaigne D. Contrasting effects of diabetes and metabolic syndrome on post-operative atrial fibrillation and in-hospital outcome after cardiac surgery.

Int J Cardiol. 2012;167(5):2347-50.

 

Klug D, Boule S, Wissocque L, Montaigne D, Marechal X, Hassoun SM, Neviere R.

Right ventricular pacing with mechanical dyssynchrony causes apoptosis interruptus and calcium mishandling.

Can J Cardiol. 2013;29(4):510-8.

 

Lancel S, Montaigne D, Marechal X, Marciniak C, Hassoun SM, Decoster B, Ballot C, Blazejewski C, Corseaux D, Lescure B, Motterlini R, Neviere R. Carbon monoxide improves cardiac function and mitochondrial population quality in a mouse model of metabolic syndrome.

PLoS One. 2012;7(8):e41836.

 

Montaigne D, Bailloeuil O, Hulin-Delmotte C, Edme JL, Sosner P, Miot A, Ragot S, Saulnier PJ, Dupuy O, Gourdy P, Lecomte P, Guerci B, Dardari D, Roussel R, Neviere R, Lacroix D, Hadjadj S; DIAB2NEPHROGENE and SURDIAGENE study groups. Renal complications correlate with electrical atrial vulnerability hallmarks in type 2 diabetic patients.

Int J Cardiol. 2012 Aug 9;159(1):63-6.

 

Marechal X*, Montaigne D*, Marciniak C, et al. Doxorubicin-induced cardiac dysfunction is attenuated by ciclosporin treatment in mice through improvements in mitochondrial bioenergetics.

Clin Sci (Lond). 2011 Nov 1;121(9):405-13.

 

Ennezat PV, Maréchaux S, Six-Carpentier M, Pinçon C, Sediri I, Delsart P, Gras M, Mounier-Véhier C, Gautier C, Montaigne D, Jude B, Asseman P, Le Jemtel TH. Renal resistance index and its prognostic significance in patients with heart failure with preserved ejection fraction.

Nephrol Dial Transplant. 2011 Dec;26(12):3908-13.

 

Neviere R, Montaigne D, Benhamed L, et al. Cardiopulmonary response following surgical repair of pectus excavatum in adult patients.

Eur J Cardiothorac Surg. 2011 Aug;40(2):e77-82.

 

Maréchaux S, Six-Carpentier MM, Bouabdallaoui N, Montaigne D, Bauchart JJ, Mouquet F, Auffray JL, Le Tourneau T, Asseman P, Lejemtel TH, Ennezat PV. Prognostic importance of comorbidities in heart failure with preserved left ventricular ejection fraction.

Heart Vessels. 2011 May;26(3):313-20.

 

Montaigne D, Marechal X, Preau S, Baccouch R, Modine T, Fayad G, Lancel S, Neviere R. Doxorubicin induces mitochondrial permeability transition and contractile dysfunction in the human myocardium.

Mitochondrion. 2011 Jan;11(1):22-6.

 

Huerre C, Guiot A, Maréchaux S, Auffray JL, Bauchart JJ, Montaigne D, Mouquet F, Lesenne M, Puisieux F, Goldstein P, Asseman P, Ennezat PV. Functional decline in elderly patients presenting with acute coronary syndromes: impact on midterm outcome.

Arch Cardiovasc Dis. 2010 Jan;103(1):19-25.

 

Ennezat PV, Juthier F, Maréchaux S, Mouquet F, Bauchart JJ, Auffray JL, Montaigne D, Asseman P, Vincentelli A. Atrial septal defect associated with dilated cardiomyopathy in the setting of acute cardiac failure: importance of comprehensive bedside echocardiography in ICU.

Eur J Echocardiogr. 2010 May;11(4):E11.

 

Neviere R, Hassoun SM, Decoster B, Bouazza Y, Montaigne D, Maréchal X, Marciniak C, Marchetti P, Lancel S. Caspase-dependent protein phosphatase 2A activation contributes to endotoxin-induced cardiomyocyte contractile dysfunction.

Crit Care Med. 2010 Oct;38(10):2031-6.

 

Montaigne D, Marechal X, Baccouch R, Modine T, Preau S, Zannis K, Marchetti P, Lancel S, Neviere R. Stabilization of mitochondrial membrane potential prevents doxorubicin-induced cardiotoxicity in isolated rat heart.

Toxicol Appl Pharmacol. 2010 May 1;244(3):300-7.

 

Joulin O, Marechaux S, Hassoun S, Montaigne D, Lancel S, Neviere R. Cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in LPS-treated rats.

Crit Care. 2009;13(1):R14.

 

Gilleron M, Marechal X, Montaigne D, Franczak J, Neviere R, Lancel S. NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis.

Biochem Biophys Res Commun. 2009 Oct 30;388(4):727-31.

 

Bouallal R, Montaigne D, Fayad G, Auffray JL, Asseman P, Ennezat PV. Late bioprosthetic mitral valve thrombosis: a link with postoperative heparin-induced thrombocytopenia?

J Am Soc Echocardiogr. 2009 Nov;22(11):1310.e5-6. (IF 2009 = 3.0)

 

Ennezat PV, Bellouin A, Maréchaux S, Juthier F, Fayad G, Vincentelli A, Berrébi A, Auffray JL, Bauchart JJ, Mouquet F, Montaigne D, Asseman P, Le Jemtel TH, Pibarot P. Pivotal role of bedside Doppler echocardiography in the assessment of patients with acute heart failure and mitral regurgitation.

Cardiology. 2009;113(4):249-59. (IF 2009 = 0.7)

 

Montaigne D, Fayad G, Ennezat PV. Unusual cause of acute coronary syndrome.

Arch Cardiovasc Dis. 2008 Nov-Dec;101(11-12):795-6. (IF 2008 = 0.6)

 

Montaigne D, Ennezat PV, Asseman P. Forgotten needles.

Emerg Med J. 2008 Jan;25(1):61. (IF 2008 = 1.5)

 

Montaigne D, Marechal X, Lancel S, Decoster B, Asseman P, Neviere R. The synthetic pentasaccharide fondaparinux prevents coronary microvascular injury and myocardial dysfunction in the ischemic heart.

Thromb Haemost. 2008 Nov;100(5):912-9.

 

Hassoun SM, Marechal X, Montaigne D, Bouazza Y, Decoster B, Lancel S, Neviere R. Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction.

Crit Care Med. 2008 Sep;36(9):2590-6.

 

Ennezat PV, Lefetz Y, Maréchaux S, Six-Carpentier M, Deklunder G, Montaigne D, Bauchart JJ, Mounier-Véhier C, Jude B, Nevière R, Bauters C, Asseman P, de Groote P, Lejemtel TH. Left ventricular abnormal response during dynamic exercise in patients with heart failure and preserved left ventricular ejection fraction at rest.

J Card Fail. 2008 Aug;14(6):475-80.

 

Marechal X, Favory R, Joulin O, Montaigne D, Hassoun S, Decoster B, Zerimech  F, Neviere R. Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress.

Shock. 2008 May;29(5):572-6.

First and Last Name Current Position Organization
David MONTAIGNE ProfessorAcademic Cardiologist University Hospital LilleINSERM UMR 1011
Augustin COISNE Academic CardiologistPhD Student University Hospital LilleINSERM UMR 1011
Xavier MARECHAL EngineerPhD INSERM UMR 1011 Lille
Sandro NINNI Master Student, MD University Hospital LilleINSERM UMR 1011
Cédric KLEIN Master Student, MD University Hospital LilleINSERM UMR 1011