L'unité
UMR 1011 is organised into 5 themes:
Theme 1 (Nuclear Receptors in the Metabolic Syndrome) studies the metabolic functions of NRs (FXR, Rev-erbα, RORα) and their implication as potential therapeutic targets in humans.
Theme 2 (Cardiac pathologies, blood flow anomalies and haemostasis) focuses on the characterisation of macrophages in different pathologies (i.e. metabolic or cardiovascular disorders) in order to modulate their functions by pharmacological means. The relative contribution of macrophage sub-fractions, as well as that of vascular interstitial cells (VICs) in tissue remodelling and the response to vascular calcification will be studied.
Theme 3 (Immuno-metabolic dialogue in obesity and its comorbidities) studies the contribution and regulation by NRs of other cells of the immune system (mast cells, B lymphocytes) in the pathophysiology of atherosclerosis with a particular interest in PPARγ.
Theme 4 (Integrated Transcriptional Analysis of Liver Diseases) identifies the molecular mechanisms of RN-mediated regulation, in order to discover new regulatory pathways and better define molecules for therapeutic purposes.
Theme 5 (Nuclear Receptors and Circadian Rhythms in Physiopathology) has developed a new line of research dedicated to the circadian regulation of metabolism and inflammation, focusing on the components of the clock and the nuclear receptors targeted by drugs, the Rev-erbs and ROR.